Glucosamine and Chondroitin is frequently used together, here is why:

Glucosamine sulfate and chondroitin sulfate are naturally occurring substances found in the connective tissues of the body, including the cartilage that covers the ends of bones in the joints. Glucosamine sulfate functions are the primary building block in cartilage that give it viscoelastic (buffering) properties. When taken orally, glucosamine sulfate is absorbed readily and can be traced to cartilage as soon as four hours after consumption. Similar to non-steroidal anti-inflammatory drugs, glucosamine sulfate has been shown to have unique anti-inflammatory effects. Additionally, in some laboratory tests, the glucosamine supplement demonstrated a protective effect on the cartilage as well.


Glucosamine is derived from two glucose molecules that combine with three amino acids to yield Glucosamine. Glucosamine is very important as it protects cartilage and joints from further damage. The supplement may also help rebuild cartilage that has been influenced by wearing down and too much friction.

Glucosamine is used to protect joints from being damaged further by enzymes and alterations in the environment. The natural aging process and regular routines of physical activities may hinder the durability of cartilage. However, the effects of glucosamine are beneficial as they help keep muscles, joints, and other connective tissues flexible and active.

Glucosamine is used to fight a number of diseases such as osteoarthritis, osteoporosis, inflammatory arthritis, tendonitis, and diseases of joint fluidity. The natural anti-inflammatory properties of glucosamine make it beneficial for treatment of arthritis. Moreover, the supplement can relieve pain and inflammation naturally, which is another advantage of boosting the production of glycosaminoglycans and chondroitin sulfate.

Being made from naturally occurring sources, glucosamine and chondroitin sulfate are free from side effects and are safe to use. Doctors only need to prescribe the supplement to treat arthritis, and most patients only need to take it once in a while for a few months. There is no large scale clinical testing for the effectiveness of glucosamine and chondroitin sulfate. As a result, both supplements are sold outside of clinical trials.

Even if they are bought outside of clinical trials, both supplements will still be absorbed into the body. Both supplements are flushed out of the body and excreted through urine, which means that they have no significant impact on kidney function or blood. Chondroitin sulfate is proven to only have minor side effects, while glucosamine may have more side effects, but their side effects are usually less severe.

Unlike other types of arthritis, such as osteoarthritis and rheumatoid arthritis, synthetic glucosamine and chondrotin supplements are not usually used to treat osteoarthritis. Non-steroidal anti-inflammatory drugs may be injected along with non-steroidal anti-inflammatory drugs (NSAIDs) which may be taken orally. The typical course of treatment for osteoarthritis may include non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine, and steroids are often used in conjunction with an anti-inflammatory and steroids. This combination can be quite effective but can result in complications such as gastrointestinal bleeding, which must be evaluated by a doctor.

Glucosamine supplements are much safer to use, and they have no significant side effects, unlike colchicine. However, upon ordered by a doctor, colchicine is usually injected along with glucosamine supplements or both. Research has shown that there is no downtime or need for injection after using glucosamine, and that there is no loss of effectiveness when the supplement is taken with the same colchicine. Glucosamine and colchicine may be given at the same time, or alternatively, colchicine may be taken alone, with glucosamine supplements.

Glucosamine and colchicine are used to treat arthritis with inflammation, and they are effective in mild to moderate arthritis pain. Neither colchicine nor glucosamine is a fully absorbed product, meaning that both supplements need to be taken with food or another form of protein. Glucosamine is water-soluble, while colchicine is fat-soluble.

There is a difference, however, between glucosamine and its relatives, i.e., chondroitin and glucosamine sulfate. Glucosamine is absorbed into joints much easier than chondroitin, so you will get better results from both of them. But there is a downside. Since glucosamine is mostly water-soluble and doesn't stay bound to colchicine, the compound is easily filtered in the small intestine. This means that colchicine remains in the body, and may also be filtered out of the body by the liver.

Research indicates that taking both supplements at once reduces absorption anomalies in people suffering from IBS-D.1, a food allergy, but supplementing only glucosamine sulfate and not both of them worsens plumbing problems.

As a flows, Ramanathan Kothebralth, a consultant to IBS specialist, says that sometimes adding aloe vera to a formula with glucosoluble colon cleansing fluid can improve IBS-D. To flush away some of that toxic waste and keep the bowel movement of brushable materials, which increases the amount that is passed in the IBS movement, which is slowed down with constipation.

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